Angiotensin II for Septic Shock in Emergency Department

Early Angiotensin II in the Emergency Department

Recruiting Phase 4 Interventional Study
Septic Shock
No Placebo Group Every participant receives an active treatment — no one gets a placebo. Prior Safety Data This treatment has already been tested in at least one earlier human trial.
Ready to participate?

Review the details below, then apply to join this clinical trial.

At a Glance
Age
18 – 99
Sex
Any
Trial phase
Phase 4
Study type
Interventional
Purpose
Treatment
Participants needed
20 (estimated)
Sponsor
Brett A Faine · Other
Who this trial is looking for

This trial is looking for adults with septic shock who need medication support in the emergency department. Participants will receive angiotensin II to help treat their condition.

Are You a Good Fit for This Trial?

You may be able to join if

  • I am 18 years old or older.
  • I need norepinephrine despite getting enough fluids.
  • I am receiving antibiotics or my doctor plans to give me antibiotics.
  • I can provide written informed consent.

You may not be able to join if

  • I have had a heart attack.
  • I am in cardiogenic shock.
  • I have a history of mesenteric ischemia.
  • I have a history of aortic dissection or abdominal aortic aneurysm.
  • I am not expected to live more than 12 hours.
  • I am in hemorrhagic shock.
  • I am receiving two vasoactive agents before enrollment.
  • I have pre-existing thromboembolic disease or cannot take blood clot prevention medication.

Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.

Think this trial could be right for you?

Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.

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About This Trial

This pilot study will enroll 20 patients with septic shock and require emergent vasopressor support in the emergency department (ED). The primary objective of the study is to determine the feasibility of early peripheral administration of angiotensin II for treatment of septic shock in the ED

Trial Locations
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Eligibility Criteria
Inclusion Criteria 1. Age ≥18; and 2. Requiring norepinephrine at a dose of 0.05-0.25 mcg/kg/min mcg/kg/minute despite adequate fluid resuscitation; and 3. Receiving intravenous antibiotics or clinician's intention to administer antibiotics at the time of enrollment; and 4. Can provide written info…
Contacts

Brett Faine, PharmD

+1 319 356 2577

brett-faine@uiowa.edu

CONTACT