No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 – 65
Sex
Any
Study type
Observational
Participants needed
60 (estimated)
Sponsor
The Cleveland Clinic · Other
Who this trial is looking for
This trial is looking for adults with Type 1 diabetes and chronic kidney disease. Participants will be studied to see how their blood sugar levels affect certain immune cells and kidney function.
Are You a Good Fit for This Trial?
Must be takingInsulin
Must not be takingGLP-1 agonistDPP4 inhibitorSGLT2 inhibitors
You may be able to join if
I am between 18 and 65 years old.
I have been diagnosed with Type 1 diabetes.
I have chronic kidney disease.
I have albuminuria.
I use insulin injections or a pump.
I use continuous glucose monitoring.
You may not be able to join if
My hemoglobin is less than 9.
I have been on GLP-1 agonist or certain other medications in the last 30 days.
I am pregnant or planning to become pregnant.
I am taking steroids.
I have been diagnosed with cancer or an autoimmune condition.
I report heavy alcohol use or recreational drug use.
I have any condition that affects my safety or immune cells.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
This is a cross-sectional study in patients with Type 1 diabetes (TID) and chronic kidney disease (CKD) to test if time in range (TIR) affects the degree of hyperglycemia required for monocyte activation, podocyte injury, and assess if monocyte activation is attenuated by glucagon-like peptide (GLP-1) agonist treatment ex vivo.
Trial Locations
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Status
Eligibility Criteria
Inclusion Criteria:
1. T1D CKD subjects:
1. Adults, males or females diagnosed with T1D
2. Age 18-65 years
3. Diagnosed with CKD (eGFR 60-90 ml/min/1.73 m2)
4. Diagnosed with albuminuria (UACR 30-500 mg/g)
5. On insulin injections or pump
6. On CGM
Based on baseline CGM metri…
Inclusion Criteria:
1. T1D CKD subjects:
1. Adults, males or females diagnosed with T1D
2. Age 18-65 years
3. Diagnosed with CKD (eGFR 60-90 ml/min/1.73 m2)
4. Diagnosed with albuminuria (UACR 30-500 mg/g)
5. On insulin injections or pump
6. On CGM
Based on baseline CGM metrics, the investigators will stratify subjects to 2 groups Group A (Lower TIR group): TIR\<60%, A1c 7.5-9.5 Group B (Higher TIR group): TIR\>70% A1c 5.0-7.0
2. Controls: T1D subjects without CKD
1. Adults, males or females diagnosed with T1D
2. Age 18-65 years
3. No CKD (eGFR \>90 ml/min/1.73 m2)
4. No albuminuria (UACR \<30 mg/g)
5. On insulin injections or pump
6. On CGM
Based on baseline CGM metrics, the investigators will stratify subjects to 2 groups Group A (Lower TIR group): TIR\<60%, A1c 7.5-9.5 Group B (Higher TIR group): TIR\>70% A1c 5.0-7.0
Exclusion Criteria:
1. Hemoglobin \<9
2. On GLP-1 agonist or DPP4 inhibitor or sodium-glucose co-transporter-2 inhibitors use within 30 days
3. pregnancy or plans to become pregnant
4. On steroids
5. Diagnosed with cancer, immunosuppression/autoimmune conditions
6. Reported heavy alcohol use or recreational drug use
7. Any condition which jeopardizes patient safety or affects monocytes at physician's discretion
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