No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
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At a Glance
Age
18 and older
Sex
Any
Study type
Observational
Participants needed
300 (estimated)
Sponsor
Georgetown University · Other
Who this trial is looking for
This trial is looking for stroke survivors and older adults who have difficulties with reading. Participants will take part in tests about their reading and thinking abilities, and some may have an MRI scan.
Are You a Good Fit for This Trial?
You may be able to join if
I am at least 18 years old
I learned English at 8 years old or younger
I have had a brain injury from a stroke
You may not be able to join if
I have a history of another brain disorder that affects results
I have a severe psychiatric condition that affects my participation
I have a diagnosed learning disorder
I have hearing or vision loss that I cannot correct
I cannot follow the study procedures even with help
I have metal in my body that is not safe for an MRI
I am pregnant
I have claustrophobia
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
Loss of reading ability due to stroke, called alexia, likely affects over a million Americans at any given time and causes difficulty performing many daily life functions, such as paying bills, using email/text, reading for pleasure, and reading signs in the community. Understanding the brain and cognitive basis of alexia could improve diagnosis and treatment of this important problem. In this stu…
Loss of reading ability due to stroke, called alexia, likely affects over a million Americans at any given time and causes difficulty performing many daily life functions, such as paying bills, using email/text, reading for pleasure, and reading signs in the community. Understanding the brain and cognitive basis of alexia could improve diagnosis and treatment of this important problem. In this study, the investigators will perform a large-scale behavioral and brain imaging study of stroke survivors and typical older adults to improve our understanding of the brain and cognitive basis of reading in both of these groups.
Participants will complete a battery of tests of reading, speech, language, and thinking abilities. In addition, some participants will complete an MRI. Sessions will be completed across approximately 2-6 weeks, but may be extended depending on participants' schedules and availability. Some participants will be invited to repeat these procedures once or twice in approximately 3-12 months to monitor for changes in reading abilities and MRI measurements over time.
Trial Locations
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State
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Status
Eligibility Criteria
Inclusion criteria:
Stroke Survivors:
* Age \>= 18
* Learned English at 8 years or younger
* Brain injury resulting from stroke
Controls:
* Age \>= 18
* Learned English at 8 years or younger
Exclusion criteria for all groups:
* History of other brain disorder that could interfere with our abil…
Inclusion criteria:
Stroke Survivors:
* Age \>= 18
* Learned English at 8 years or younger
* Brain injury resulting from stroke
Controls:
* Age \>= 18
* Learned English at 8 years or younger
Exclusion criteria for all groups:
* History of other brain disorder that could interfere with our ability to interpret results (e.g., Multiple sclerosis, dementia, head injury causing loss of consciousness)
* Severe psychiatric condition that would interfere with participation in the study
* History of diagnosed learning disorder
* Hearing or vision loss that interferes with performance on behavioral tests even after correction with glasses/hearing aids.
* Inability to follow study procedures despite maximal support
Additional exclusion criteria for MRIs:
* Presence of metal in the body that is incompatible with MRI
* Pregnancy
* Claustrophobia
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