Comparison of Clinical Efficacy of Submucosal Dexamethasone and Oral Trypsin-chymotrypsin for Reduction of Postoperative Sequelae After Lower Third Molar Surgery
Recruiting
N/A
Interventional Study
Clinical Efficacy of Submucosal Dexamethasone and Oral Trypsin Chymotrypsin for Reduction of Postoperative Sequelae After Lower Third Molar Surgery
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
At a Glance
- Age
- 18 and older
- Sex
- Any
- Study type
- Interventional
- Purpose
- Treatment
- Participants needed
- 50 (estimated)
- Sponsor
- B.P. Koirala Institute of Health Sciences · Other
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About This Trial
Pain, edema and trismus are the most frequent postoperative sequelae to surgical removal of impacted teeth, all of are due to the local inflammatory response.
Use of corticosteroids decrease tissue mediators of inflammation and reduce edema.
Use of trypsin-chymotrypsin elaborates the enzymes esterase in blood plasma that inhibits inflammation by hydrolytic degradation of the inflammatory peptide…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Clinically healthy patients (ASA I) patient free of any systemic diseases that could interfere with wound healing or surgical operation.
* Free of any recent anti-inflammatory drug intake or being under long term treatment with medicaments that will obscure the assessment of t…
Contacts