Aerobic Exercise and Its Impact on Sensory, Musculoskeletal, and Psychosocial Aspects in Migraine
Recruiting
N/AInterventional Study
MigraineMigraine DiseaseMigraine DisorderMigraine Disorders, BrainHeadacheHeadache (Migraine)Headache DisordersHeadache Disorders, PrimaryAerobic ExercisePain ManagementSensory DisordersPsychosocial FactorsQuality of Life
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Ready to participate?
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At a Glance
Age
18 – 48
Sex
Female
Study type
Interventional
Purpose
Treatment
Participants needed
100 (estimated)
Sponsor
University of Sao Paulo · Other
Who this trial is looking for
This trial is looking for women aged 18 to 48 who have migraines. Participants will take part in a supervised exercise program three times a week for 16 weeks, along with educational sessions about pain management.
Are You a Good Fit for This Trial?
You may be able to join if
I am a woman aged between 18 and 48 years.
I have been diagnosed with migraines by a specialist.
I have headaches 3 to 8 days per month.
You may not be able to join if
I have any other type of headache.
I have medical conditions affecting sensitivity or nerve function.
I have severe injuries or diseases that prevent physical activity.
I have had premature ovarian failure.
I have exercised regularly in the past year.
My Body Mass Index (BMI) is above 30.0.
I smoke or use certain drugs that affect sensitivity.
I abuse medications used to relieve migraines.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
Migraine is a neurological disorder associated with high levels of disability and changes in sensory processing, musculoskeletal function, and psychosocial factors. Aerobic exercise is a low-cost, non-pharmacological strategy that has shown potential benefits for migraine management, but its effects on sensory perception and musculoskeletal function are not yet fully understood.
This randomized c…
Migraine is a neurological disorder associated with high levels of disability and changes in sensory processing, musculoskeletal function, and psychosocial factors. Aerobic exercise is a low-cost, non-pharmacological strategy that has shown potential benefits for migraine management, but its effects on sensory perception and musculoskeletal function are not yet fully understood.
This randomized controlled trial will investigate the effects of a supervised aerobic exercise program combined with pain neuroscience education compared with an active control condition in women aged 18 to 48 years diagnosed with migraine. Participants will be randomly allocated to either an intervention group, which will perform supervised aerobic exercise three times per week for 16 weeks and receive one session of pain neuroscience education, or a control group, which will receive recommendations for unsupervised physical activity at home.
Outcomes related to migraine-related disability, self-reported symptoms, sensory sensitivity, and musculoskeletal function will be assessed at baseline and after the intervention period. Questionnaires will also be collected at a 6-month follow-up. The results of this study may contribute to the development of accessible and low-risk non-pharmacological treatment strategies for people with migraine.
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Eligibility Criteria
Inclusion Criteria:
* Women aged between 18 and 48 years.
* Diagnosed with migraine by an experienced neurologist specialized in headaches, following the criteria of the International Classification of Headache Disorders (ICHD).
* Frequency of headache between 3 and 8 days per month, to ensure adhe…
Inclusion Criteria:
* Women aged between 18 and 48 years.
* Diagnosed with migraine by an experienced neurologist specialized in headaches, following the criteria of the International Classification of Headache Disorders (ICHD).
* Frequency of headache between 3 and 8 days per month, to ensure adherence to the treatment.
Exclusion Criteria:
* Presence of any other type of concurrent headache.
* Medical conditions affecting sensitivity and autonomic modulation, such as peripheral neuropathies, autonomic disorders, severe neurological diseases, and others.
* Conditions that prevent physical activity, such as severe musculoskeletal injuries, cardiovascular diseases, or related conditions.
* Premature ovarian failure.
* Regular physical exercise in the past year.
* Body Mass Index (BMI) above 30.0.
* Smokers or individuals using drugs that interfere with sensitivity and cardiac modulation (e.g., beta-blockers).
* Abuse of abortive medications.
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