Impact of a TDM-guided ECPA Program for Optimizing Pharmacodynamic Target Attainment of Continuous Infusion Beta-lactam-based Regimen
Recruiting
Observational Study
Liver Transplant Infection
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
At a Glance
- Age
- 18 and older
- Sex
- Any
- Study type
- Observational
- Participants needed
- 65 (estimated)
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna · Other
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About This Trial
Previous studies have clearly demonstrated a significant impact of optimised antibiotic therapy based on a TDM-guided approach in reducing the clinical and microbiological failure rate and in improving the achievement of an optimal pharmacokinetic/pharmacodynamic target. However, no study has yet evaluated this aspect in the specific scenario of liver transplant patients with documented infections…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
1. adult OLT recipients (age ≥ 18 years);
2. documented Gram-negative infections occurring in the first 90 days after transplantation;
3. treatment with beta-lactam based-regimens;
4. signed informed consent.
Exclusion Criteria:
1. patients receiving beta-lactam-based regimens…
Contacts