Using Radiotherapy and Immunotherapy to Treat Advanced Liver Cancer Before Transplant

Recruiting Phase 1 Phase 2 Interventional Study
Hepatocellular Carcinoma (HCC) Macrovascular Invasion Liver Transplant Surgery Downstaging
No Placebo Group Every participant receives an active treatment — no one gets a placebo. Prior Safety Data This treatment has already been tested in at least one earlier human trial.
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At a Glance
Age
18 – 70
Sex
Any
Trial phase
Phase 1/2
Study type
Interventional
Purpose
Treatment
Participants needed
48 (estimated)
Sponsor
University Health Network, Toronto · Other
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About This Trial
The goal of this clinical trial is to learn if locoregional therapy and immunotherapy can be used together to help patients with hepatocellular carcinoma (HCC) and macrovascular invasion achieve liver transplantation. The main questions it aims to answer are: * How many patients will achieve transplant with this treatment strategy? * What will the 5-year survival and recurrence-free survival rat…
Trial Locations
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Eligibility Criteria
Inclusion Criteria: * Age 18-70 * Weight \> 30 kg * Child Pugh Turcotte score A5 to B7 * Macrovascular invasion (Vp1-3) * Total tumour volume \< 350 cm3 * Alpha Fetoprotein \< 5000 ng/mL * No extrahepatic disease * No other contraindications to undergo a LT * Eastern Cooperative Oncology Group (ECO…
Contacts

Clinical Research Manager

437-772-4354

roxana.bucur@uhn.ca

CONTACT