Amiodarone-Infused CardiaMend Patches for the Prevention of New-Onset POAF in Cardiac Surgery Subjects

Inclusion Criteria: * Subjects 20-85 years old. * Subjects able to give voluntary written informed consent, who understand and are willing to comply with study-related procedures. * Subjects scheduled to undergo open-chest cardiac surgery via complete median sternotomy. * Subjects in sinus rhythm at the time of office visit and during prior EKG (note: continuous EKG monitoring for 48 hours is not required). Exclusion Criteria: * Subjects unable to give voluntary written informed consent, unlikely to cooperate, or legally incompetent, including subjects institutionalized by court or official order, or in a dependency relationship with testing center or investigator. * Subjects with a condition that could interfere with their ability to comply with the study. * Subjects participating in an interventional clinical study or who have participated in such study during the preceding 30 days. * Female subjects who are pregnant, breastfeeding, were pregnant within the last three months, or are planning to become pregnant during the study. * Subjects with active skin or deep infection at the site of implantation. * Subjects with a history of chronic wounds or wound-healing disorders. * Subjects with known connective tissue diseases (e.g. Ehlers-Danlos syndrome, Epidermolysis bullosa, Marfan syndrome, Osteogenesis imperfecta). * Subjects who are Immune-suppressed or with immune deficiency (properly managed diabetes mellitus is not an exclusion criterion). * Subjects on concomitant oral or IV systemic corticosteroid therapy and/or other constant anti-inflammatory therapies. * Subjects on the following medications with known interactions with amiodarone: doxorubicin, fosphenytoin, lopinavir-ritonavir, ledipasvir/sofosbuvir, quinidine , procainamide, disopyramide, other Vaughan William class III agents including dofetilide, dronedarone, ibutilide and vernakalant. * Subjects with coadministration of any medications which cause QT prolongation * Subjects with implantable cardiac devices (i.e., cardiac resynchronization therapy devices with and without defibrillator capabilities (CRTs and CRT-Ds), implantable cardioverter-defibrillators (ICD), and pacemakers). * Subjects with a known history of atrial fibrillation or paroxysmal atrial fibrillation. * Subjects with a history of ablation for atrial fibrillation. * Subjects already receiving amiodarone as a treatment for atrial fibrillation or ventricular arrhythmias. * Subjects with a disease of the left pleura, previous intervention in the left pleural space, or chest deformity. * Subjects with heart failure (BNP\>1000), low ejection fraction (\<35%), end-stage renal disease (on dialysis or GFR\<20). * Subjects electing to receive an ablative procedure for atrial fibrillation during the index operation. * Subjects with prior cardiac surgery via sternotomy.