RD13-02 Cell Injection in Patients with Relapsed or Refractory CD7-Positive Natural Killer/T Cell Malignancies

Recruiting Phase 1 Interventional Study
NK T-Cell Lymphoma CART Therapy CD7-positive Relapsed/Refractory Lymphoid Hematologic Malignancies
No Placebo Group Every participant receives an active treatment — no one gets a placebo.
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At a Glance
Age
3 – 70
Sex
Any
Trial phase
Phase 1
Study type
Interventional
Purpose
Treatment
Participants needed
10 (estimated)
Sponsor
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology · Other
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About This Trial

This is a single-arm, open-label, single-center, phase I study. The primary objective is to evaluate the safety of CD7 Chimeric Antigen Receptor-T(CAR-T) therapy for patients with CD7-positive relapsed or refractory natural killer/T cell lymphoma, and to evaluate the pharmacokinetics of CD7 CAR-T in patients。

Trial Locations
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Eligibility Criteria
Inclusion Criteria: 1. Age 3-70 2. Diagnosis of r/r NK/T lymphoma. 3. CD7 positive expression 4. Bone marrow lymphoblasts ≥5% by morphologic evaluation at screening 5. Creatinine clearance (as estimated by Cockcroft Gault) ≥ 60 mL/min, Serum alanine aminotransferase(ALT)/aspartate aminotransferase(…
Contacts

Heng Mei, Ph.D&M.D

027-8572600

hmei@hust.edu.cn

CONTACT

Yinqiang Zhang

15007101371

zhang_yq@hust.edu.cn

CONTACT