Tirzepatide After Sleeve Gastrectomy for Obesity

Randomized Control Trial of Sleeve Gastrectomy With Tirzepatide in Maximizing Weight Loss

Recruiting Early Phase 1 Interventional Study
Obesity and Obesity-related Medical Conditions
No Placebo Group Every participant receives an active treatment — no one gets a placebo.
Ready to participate?

Review the details below, then apply to join this clinical trial.

At a Glance
Age
18 – 65
Sex
Any
Trial phase
Early Phase 1
Study type
Interventional
Purpose
Treatment
Participants needed
42 (estimated)
Sponsor
Nicholas Skertich · Other
Who this trial is looking for

This trial is looking for adults with obesity who are undergoing sleeve gastrectomy surgery. Participants will take the medication tirzepatide to see if it helps them lose more weight and improve related health conditions after surgery.

Are You a Good Fit for This Trial?
Rules you out Diabetic retinopathyGastroparesis

You may be able to join if

  • I am between 18 and 65 years old.
  • I have a Body Mass Index (BMI) over 35 with health issues like Type 2 diabetes or high blood pressure.
  • I have a BMI over 40.
  • I am having primary sleeve gastrectomy surgery.

You may not be able to join if

  • I have had metabolic or bariatric surgery before.
  • I have used a GLP-1 agonist
  • I have a history of pancreatitis.
  • I have a personal or family history of medullary thyroid cancer.
  • I have an eating disorder.
  • I am pregnant or breastfeeding.
  • I have had a heart attack or stroke.
  • I have active cancer.

Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.

Think this trial could be right for you?

Answer a few quick questions to see if you may meet the eligibility requirements.

Check Your Eligibility
About This Trial

This study examines whether adding tirzepatide-a medication that helps with weight loss-after sleeve gastrectomy surgery can help people lose more weight after the surgery; better improve conditions like Type 2 diabetes, high blood pressure, high cholesterol, and sleep apnea after surgery and; whether this causes more complications or side effects compared to surgery alone.

Trial Locations
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Eligibility Criteria
Inclusion Criteria: * Adult 18 to 65 years of age * Body Mass Index \>35 with comorbidity of Type 2 Diabetes and/or Hypertension and/or Hyperlipidemia and/or Obstructive Sleep Apnea OR Body Mass Index \>40 with or without comorbidity * Undergoing primary sleeve gastrectomy Exclusion Criteria: * P…
Contacts

Research Administrator

312-942-5500

anna_t_alecci@rush.edu

CONTACT