Tranexamic Acid in Patients With Traumatic Bleeding Based on Dynamic Monitoring of Thromboelastography
Recruiting
Phase 4
Interventional Study
Trauma Coagulopathy
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
At a Glance
- Age
- 18 – 80
- Sex
- Any
- Trial phase
- Phase 4
- Study type
- Interventional
- Purpose
- Treatment
- Participants needed
- 580 (estimated)
- Sponsor
- Nanfang Hospital, Southern Medical University · Other
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About This Trial
Trauma is an important global public health problem and is the leading cause of death in people under 40 years old. Studies have shown that early prehospital administration of TXA 1 g intravenously followed by a continuous infusion of 1 g tranexamic acid (TXA) over 8 hours ( 1+1 regimen) is effective in reducing mortality in trauma patients, but there is a residual risk of death. This clinical stu…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
1. . trauma patients 18 -80 years of age (50 points \> trauma ISS score \> 16);
2. . hypotension (systolic blood pressure ≤ 90 mm Hg) and/or tachycardia (heart rate ≥ 110 beats/min);
3. . receiving a 1 g TXA push within 3 h of the injury, with the push completed within 10 min of…
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