JMKX000197 Injection for Malignant Pleural Effusion

Inclusion Criteria: 1. The participant voluntarily joined the study, signed an informed consent form, and had good compliance. 2. Age ≥ 18 years and ≤ 75 years old, regardless of gender. 3. Participants with advanced solid tumors diagnosed by histopathology or cytopathology. 4. Malignant pleural effusion confirmed by histopathology or cytopathology or clinically diagnosed as moderate or above and requiring drainage. 5. Eastern Cooperative Oncology Group (ECOG) performance status: 0 to 2. 6. Life expectancy of at least 3 months. 7. Adequate organ function. 8. Female participants of childbearing potential should agree to use contraception to prevent pregnancy until 6 months after discontinuation of JMKX000197. The serum pregnancy test result should be negative 7 days before enrollment and must be a non-lactating participant. Male participants must agree to use effective contraception during the study and for 6 months after discontinuation of JMKX000197. Exclusion Criteria: 1. Bilateral pleural effusion or concurrent peritoneal effusion, or concurrent pericardial effusion. 2. Pleural effusion is either encapsulated or severely separated; Or merge with chylothorax; Or combined with infectious pleural effusion. 3. Have used interferon gene stimulating factor (STING) agonists for pleural perfusion。 4. Known allergies to the study drug or its excipient components. 5. Have participated in other clinical trials within 28 days prior to randomization. 6. Major surgery within 28 days prior to randomization. 7. Central nervous system metastatic disease, leptomeningeal disease, or cord compression. 8. Clinical unstable or uncontrolled concomitant cardiovascular, pulmonary, hepatic, renal or seizures diseases. 9. Uncontrollable systemic infections (viruses, bacteria, fungi), including but not limited to positive HBsAg and HBV DNA, positive HCV RNA, positive HIV antibody test or combined infections within the first 28 days of randomization and require systemic anti-infective treatment. 10. Have a history of organ transplantation. 11. Any further condition which, in the opinion of the Investigator, the participant is not suitable in the present study.