Pre-operative Intra-nasal Dexmedetomidine or Insulin for Prevention of Early Post-operative Cognitive Dysfunction in Patients Undergoing Elective Coronary Artery Bypass Graft.
Recruiting
Early Phase 1
Interventional Study
Post Operative Cognitive Dysfunction
At a Glance
- Age
- 60 – 75
- Sex
- Any
- Trial phase
- Early Phase 1
- Study type
- Interventional
- Purpose
- Treatment
- Participants needed
- 150 (estimated)
- Sponsor
- Minia University · Other
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About This Trial
On pump coronary revascularization is a very common leading cause for post-operative cognitive dysfunction regarding patient age grouping and diffuse systemic inflammatory response induced by bypass machine . Many factors are incriminated as pre-operative sleep disturbance, previous history of neurocognitive dysfunction. The accumulating evidence refers to an incidence between 20-40% with majority…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Adult population, 60 years or above, both sex, candidate for elective on pump coronary revascularization
Exclusion Criteria:
* patient refusal
* combined reperfusion and valve replacement operations.
* Emergency or redo CABG.
* preoperative MMSE score less than 20
* preopera…
Contacts