Breathing Muscle Training for Menopausal Hot Flashes
Time-Efficient Inspiratory Muscle Strength Training for Reducing Sympathetic Activity and Improving Sleep in Midlife Women
Recruiting
N/AInterventional Study
MenopauseHot FlashesBlood Pressure Regulation
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
45 – 60
Sex
Female
Study type
Interventional
Purpose
Basic Science
Participants needed
30 (estimated)
Sponsor
Mayo Clinic · Other
Who this trial is looking for
This trial is looking for women aged 45-60 who experience hot flashes. Participants will learn how to train their breathing muscles to see if it can help with their symptoms and improve sleep.
Are You a Good Fit for This Trial?
You may be able to join if
I am a woman aged 45-60.
I experience hot flashes.
I do not smoke.
My BMI is less than 40.
I have no history of cardiovascular disease, except for high blood pressure.
You may not be able to join if
I have a history of spontaneous pneumothorax.
I have a collapsed lung that has not fully healed.
I have a perforated eardrum that has not fully healed.
I use sleep aids like prescription medications or melatonin.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
The purpose of this research is to understand how training the muscles used for breathing (inhalation) affects menopausal hot flashes, sympathetic nerve activity and sleep.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Females aged 45-60 with hot flashes.
* Participants will be recruited from Rochester, MN and surrounding areas.
* Non-smokers.
* BMI \< 40kg/m\^2.
* No history of cardiovascular disease, except for hypertension.
Exclusion Criteria:
* Detailed medical and social histories wil…
Inclusion Criteria:
* Females aged 45-60 with hot flashes.
* Participants will be recruited from Rochester, MN and surrounding areas.
* Non-smokers.
* BMI \< 40kg/m\^2.
* No history of cardiovascular disease, except for hypertension.
Exclusion Criteria:
* Detailed medical and social histories will be collected. To allow for ecological validity, participants will not be excluded for use of menopausal hormone therapy or medications affecting cardiovascular function so long as they have been on a consistent regimen for ≥3 months and during the study period. This approach to medications is consistent with recent work in this area.
* Participants will be screened for contraindications to inspiratory muscle strength training including, a history of spontaneous pneumothorax, collapsed lung that has not healed fully, a perforated eardrum that has not healed fully, and/or any other condition of the eardrum.
* Additional exclusion criteria will include the use of sleep aids (i.e., prescription, melatonin, doxylamine, valerian root, etc.).
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