The Safety and Efficacy of Pressurized Intraperitoneal Aerosol Chemotherapy for Peritoneal Metastatic Adenocarcinoma

Inclusion Criteria: 1. Histopathology verified that peritoneal metastatic adenocarcinoma (PMA) arises from gastric, colorectal, appendiceal, or ovarian carcinoma; 2. Applicable to individuals of either sex, aged between 18 and 75 years; 3. Eastern Cooperative Oncology Group (ECOG) scale ≤ 2; 4. Absence of other concurrent malignancies; 5. Without contraindications for laparoscopic surgery; 6. Laboratory testing: blood routine examination: neutrophil count ≥ 1.5× 10\^9/L, platelet count ≥ 80 × 10\^9/L, hemoglobin ≥ 80g/L ; blood biochemistry: serum total bilirubin ≤ 1.5 ×ULN, Alanine transaminase and aspartate aminotransferase ≤ 2.5 ×ULN, serum creatinine ≤ 1.5 ×ULN; 7. Life expectancy \> 6 months; 8. Informed consent understood and signed. Exclusion Criteria: 1. Presenting symptoms of gastrointestinal obstruction; 2. Fully reliant on parenteral nutrition; 3. Exhibiting decompensated ascites; 4. Suffering from severe abdominal infection (indications of peritonitis); 5. Characterized by extensive adhesions in the abdominal cavity; 6. Concurrently undergoing cytoreductive surgery (CRS) or gastrointestinal tract resection and reconstruction procedures; 7. With portal vein thrombosis; 8. Concurrently, individuals with significant or unmanaged medical conditions or infections (including atrial fibrillation, angina, cardiac dysfunction, ejection fraction \< 50%, refractory hypertension etc.); 9. Previous chemotherapeutic drugs allergy; 10. Severe cardiopulmonary, hepatonephric, hematologic, and metal diseases, or drug abuse; 11. Pregnancy or lactating women; 12. Engage in additional clinical trials within three months preceding recruitment; 13. Other conditions: patients are inappropriately included as determined by researchers.