Ketamine Sedation As Neuroprotective Agent Following Out-of-hospital Cardiac Arrest
Recruiting
Phase 2
Interventional Study
Out-of-hospital Cardiac Arrest (OHCA)
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
At a Glance
- Age
- 18 and older
- Sex
- Any
- Trial phase
- Phase 2
- Study type
- Interventional
- Purpose
- Treatment
- Participants needed
- 282 (estimated)
- Sponsor
- Christian Hassager · Other
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About This Trial
OHCA is a critical medical emergency with significant mortality and morbidity primarily due to hypoxic-ischemic brain injury (HIBI). Despite advances in resuscitation techniques, the neurological outcomes for survivors remain poor. Current post-resuscitation practices lack specific neuroprotective strategies. Ketamine, an N-Methyl-D-Aspartate (NMDA) receptor antagonist, has shown potential neuropr…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Adults (age ≥18 years) AND
* resuscitated OHCA of presumed cardiac cause with a shockable first recorded heart rhythm AND
* mean arterial pressure (MAP) \>40 mmHg AND
* a decision to perform prehospital intubation.
Exclusion Criteria:
* Advanced life support termination-of-r…
Contacts