New Mechanisms of Obesity
Recruiting
N/A
Interventional Study
Obesity and Overweight
Insulin Resistance
Obesity and Obesity-related Medical Conditions
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
At a Glance
- Age
- 15 – 22
- Sex
- Any
- Study type
- Interventional
- Purpose
- Basic Science
- Participants needed
- 55 (estimated)
- Sponsor
- Yale University · Other
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About This Trial
Given the pervasiveness of Pediatric Obesity, it is imperative to understand its pathophysiology and develop alternative strategies to reverse this condition. Herein, investigators propose to elucidate the interaction between colonic fermentation and insulin resistance in modulating metabolism in youth with obesity.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Age 15 to 22 years
* In puberty (girls and boys: Tanner stage III-V);
* BMI \>85th
Exclusion Criteria:
* Pregnancy;
* endocrinopathies (e.g., Cushing syndrome);
* substance abuse;
* medications affecting insulin resistance such as metformin, GLP-1 analogues; -
* high fibers …
Contacts