High Intensity Interval Training in Patients With a Right Ventricle to Pulmonary Artery Conduit

Inclusion Criteria: 1. Congenital absence of an unobstructed connection between the right ventricle and pulmonary artery, requiring surgical implantation of a right ventricle to pulmonary artery conduit, including patients with: 1. Truncus arteriosus 2. Pulmonary atresia with ventricular septum defect 3. Severe tetralogy of Fallot 4. Other forms of pulmonary atresia with biventricular correction 2. Age 12 to 45 years. 3. Current follow-up in Academic Center for Congenital Heart Disease (ACAHA; Erasmus MC Rotterdam and Radboudumc Nijmegen). 4. Signed informed consent. Exclusion Criteria: 1. Ventricular arrhythmias and/or channelopathy. 2. Implantable cardioverter defibrillator implantation due to inherited arrhythmia syndromes. 3. Left ventricular ejection fraction and/or right ventricular ejection fraction less than 30 percent. 4. Elite athletes (i.e. national team, Olympians, professional athletes, exercising equal to or more than 10 h/week, according to definition in 2020 European Society of Cardiology Guidelines for Sports Cardiology and Exercise in Patients with Cardiovascular Disease). 5. Cardiovascular lesions requiring intervention (according to international guidelines). 6. Cardiovascular intervention (surgery or catheterization) less than 6 months ago. 7. Cardiovascular medication changes less than 3 months ago. 8. Hospitalization for treatment of cardiovascular events less than 6 months ago. 9. Comorbidities or developmental delay impeding exercise training (e.g. neuromuscular disease, symptomatic myocardial ischemia, syndromic diagnoses such as trisomy 21). 10. Inability to provide informed consent.