B Vitamin Therapy for Parkinson's Disease Management

Pilot Study of Open Label Homocysteine Management Therapy in Levodopa-treated Parkinson's Disease

Recruiting N/A Interventional Study
Parkinson&Amp;#39;s Disease
No Placebo Group Every participant receives an active treatment — no one gets a placebo.
Ready to participate?

Review the details below, then apply to join this clinical trial.

At a Glance
Age
40 – 90
Sex
Any
Study type
Interventional
Purpose
Treatment
Participants needed
150 (estimated)
Sponsor
Oregon Health and Science University · Other
Who this trial is looking for

This trial is looking for people with Parkinson's disease who are taking levodopa. Participants will receive B vitamin therapy to see if it can help lower their homocysteine levels and improve thinking skills.

Are You a Good Fit for This Trial?
Must be taking Levodopa

You may be able to join if

  • I have been diagnosed with Parkinson's disease.
  • I take at least 300 mg of levodopa every day.
  • I am between 40 and 90 years old.
  • I have a cognitive assessment score of at least 15.
  • I can give informed consent.
  • My kidney function is normal.
  • I do not have uncontrolled high blood pressure.

You may not be able to join if

  • I use insulin.
  • I have uncontrolled hypertension.

Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.

Think this trial could be right for you?

Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.

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About This Trial

This is a research study investigating elevated homocysteine in the blood of patients with Parkinson's disease who are currently receiving treatment with levodopa. We are evaluating if elevated homocysteine can be corrected using open label B vitamin therapy, as well as the impact of homocysteine levels on cognitive function.

Trial Locations
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Eligibility Criteria
Inclusion Criteria: 1. Diagnosis of probable Parkinson's Disease according to Movement Disorders Society criteria. 2. Currently treated with levodopa at a minimum dose of 300 mg/day 3. Montreal Cognitive Assessment (MOCA) ≥15 4. Demonstrated capacity to provide informed consent. 5. 40-90 years of a…
Contacts

Madeline Armendariz Sullivan

503-501-8478

PDResearch@ohsu.edu

CONTACT