Upper Airway Inflammation and Olfaction: Mechanisms of Loss and Recovery
Recruiting
N/A
Interventional Study
Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
At a Glance
- Age
- 18 – 70
- Sex
- Any
- Study type
- Interventional
- Purpose
- Basic Science
- Participants needed
- 140 (estimated)
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain · Other
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About This Trial
The goal of this clinical trial is to understand the mechanisms leading to olfactory dysfunction (OD) in chronic rhinosinusitis (CRS). The main questions it aims to answer are:
* Is the type 2 inflammation impacting the olfactory epithelium regeneration, leading to OD?
* Does a treatment interfering with one of the major T2 inflammatory cytokines, have an impact on the mechanisms of OD in CRS?
P…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* At least two of the following symptoms: nasal obstruction, rhinorrhoea, smell loss, facial pain for 12 weeks.
* Endoscopic visualisation of bilateral sinonasal polyps
* SSI (TDI) \< 30.75 and decreased sense of smell subjectively
* Eosinophilia \> 300/μl of blood Ku/l
* On a s…
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