MR Elastography for Assessing Liver Fibrosis in Chronic Hepatitis B
Recruiting
Observational Study
Chronic Hepatitis BLiver Fibrosis
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
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At a Glance
Age
18 – 80
Sex
Any
Study type
Observational
Participants needed
600 (estimated)
Sponsor
Shengjing Hospital · Other
Who this trial is looking for
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How to construct a non-invasive, accurate, and convenient method to evaluate the severity of liver fibrosis (LF) is an important general problem in the management of patients with chronic hepatitis B (CHB). We plan to investigate the ability of magnetic resonance elastography (MRE) to grade fibrosis in chronic hepatitis B and apply to clinical longitudinal follow-up.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Age ≥ 18 years old
* Confirmed CHB (laboratory, imaging and clinical tests)
* MRE within 6 months before and after liver biopsy
* Treatment-naïve
* Child-Pugh Grade A (\<7 points)
* Written informed consent in prospective follow-up cohort
Exclusion Criteria:
* Patients with …
Inclusion Criteria:
* Age ≥ 18 years old
* Confirmed CHB (laboratory, imaging and clinical tests)
* MRE within 6 months before and after liver biopsy
* Treatment-naïve
* Child-Pugh Grade A (\<7 points)
* Written informed consent in prospective follow-up cohort
Exclusion Criteria:
* Patients with liver malignant tumor
* Chronic hepatitis due to other causes (such as alcoholic hepatitis)
* CHB combined with hepatitis C, hepatitis D, or HIV
* Patients with biliary tract diseases
* Contraindications of MRE examination, MRE failure
* Poor pathological effect
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