Impact of Sevoflurane Versus Propofol on Postoperative Delirium in Elderly Diabetic Patients Undergoing Non-Cardiac Surgery: a Multicenter, Randomized Controlled Trial
Recruiting
N/A
Interventional Study
Postoperative Delirium (POD)
Diabetes
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
At a Glance
- Age
- 60 and older
- Sex
- Any
- Study type
- Interventional
- Purpose
- Prevention
- Participants needed
- 450 (estimated)
- Sponsor
- Xijing Hospital · Other
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About This Trial
The present study is a multicenter， randomized controlled clinical trial, which plans to enroll 450 diabetic patients aged more than 60 years. The participants will be randomly assigned in a 1:1 ratio and will receive either propofol or sevoflurane for intraoperative anesthesia maintenance to evaluate the impact of these two anesthetic drugs on postoperative delirium. The aim of our study is to ex…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Age ≥60 years
* Elective surgery (with an expected duration of 2 hours or more)
* ASA grade Ⅰ-Ⅲ
* Voluntary participation and informed consent obtained
* Diabetes mellitus
Exclusion Criteria:
* Pre-operative BMI≥35 kg/m² (Class II obesity or above)
* Severe hepatic dysfuncti…
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