Dexamethasone and Local Anesthetic for Scoliosis Surgery
The Effect of Dexamethasone Administration Route and Local Anesthetic Concentration on Pain, Inflammatory Response, and Neuromonitoring in Children Undergoing Scoliosis Correction
Recruiting
Phase 4Interventional Study
Scoliosis Idiopathic Adolescent
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
10 – 18
Sex
Any
Trial phase
Phase 4
Study type
Interventional
Purpose
Treatment
Participants needed
60 (estimated)
Sponsor
Poznan University of Medical Sciences · Other
Who this trial is looking for
This trial is looking for children aged 10 to 17 who are scheduled for scoliosis surgery. Participants will receive different types of treatments to help manage their pain and reduce inflammation during and after the surgery.
Are You a Good Fit for This Trial?
You may be able to join if
I am between 10 and 17 years old
I am scheduled for idiopathic scoliosis surgery
You may not be able to join if
I have an infection at the site of the procedure
I have a blood clotting disorder
I have a weakened immune system
I have a physical status of IV or higher according to ASA
I regularly take steroid medications
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
Scoliosis correction surgery in children is a complex procedure with significant risks, including postoperative pain, inflammatory response, and potential neurological complications. Effective pain control and minimizing inflammation are critical for faster recovery and improved patient outcomes. Dexamethasone is commonly used as an adjuvant in regional anesthesia due to its anti-inflammatory effe…
Scoliosis correction surgery in children is a complex procedure with significant risks, including postoperative pain, inflammatory response, and potential neurological complications. Effective pain control and minimizing inflammation are critical for faster recovery and improved patient outcomes. Dexamethasone is commonly used as an adjuvant in regional anesthesia due to its anti-inflammatory effects and ability to prolong analgesia. However, limited research exists on the optimal route of dexamethasone administration (intravenous vs. perineural) and the best local anesthetic concentration for pain management, inflammatory response, and neuromonitoring during surgery.
This study aims to compare the effects of different dexamethasone administration routes and local anesthetic concentrations on postoperative pain, inflammation (NLR, PLR), and neuromonitoring in pediatric scoliosis surgery. Results may improve regional anesthesia protocols, enhance patient safety, and offer valuable insights for clinical practice.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* \>10 and \<18 years old
* scheduled for idiopathic scoliosis surgery
Exclusion Criteria:
* included infection at the site of the regional block,
* coagulation disorders,
* immunodeficiency,
* American Society of Anesthesiologists (ASA) physical status of IV or higher,
* hist…
Inclusion Criteria:
* \>10 and \<18 years old
* scheduled for idiopathic scoliosis surgery
Exclusion Criteria:
* included infection at the site of the regional block,
* coagulation disorders,
* immunodeficiency,
* American Society of Anesthesiologists (ASA) physical status of IV or higher,
* history of regular steroid medication.
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