A Comparison of Fisetin Kinetics in Young and Old Adults

Inclusion Criteria: * any sex * age between 18 and 30 years or ≥ 65 years * understands the study purpose and design * contractually capable and provides signed informed consent form * healthy condition or mild and/or well-treated forms of allergies, asthma, hypertension, and orthopedic diseases * a maximum of 3 chronically taken drugs Exclusion Criteria: * BMI \> 30 kg/m2 and \< 18 kg/m2 * body weight \< 48 kg * women in young cohort: known pregnancy or lactation period; positive urine pregnancy test at screening or kinetic visit * men: hemoglobin \< 8,3 mmol/l women: hemoglobin \< 7,3 mmol/l * elevated liver function tests (1 or more of ALAT, ASAT, yGT, Bilirubin \> 2x ULN) * reduced renal function (eGFRMDRD \< 60 ml/min/1,7 m2) * QTcF \> 450 ms in screening ECG * psychiatric disease requiring recent or actual treatment * drug dependency at the time of visit * use of recreational drugs more than twice a week * any known hypersensitivity or allergic reactions to fisetin * history of severe hypersensitivity reactions and/or anaphylaxis * poor venous conditions that make it impossible to place a peripheral venous catheter and regularly draw blood through it * intake of drugs undergoing extensive metabolism via CYP1A2, CYP2D6, CYP2C8, CYP2C9, CYP2C19, CYP3A4, and/or Pgp and with narrow (monitoring-requiring) therapeutic range during the past seven days if the duration of intake was at least two days * intake of COMT-inhibitors during the past seven days if the duration of intake was at least two days * intake of drugs or dietary supplements containing fisetin within the two days before or during the kinetic visits * individuals who have eaten food with high fisetin content in the two days before the kinetic visits (e.g. strawberry, apple, persimmon, grape, mango, kiwi, peach, tomato, onion, lotus roots, kale, cucumber; processed products, e.g. wine)