RTMS for Refractory Auditory Hallucinations Based on Personalized Targets Using Magnetoencephalography
Recruiting
N/AInterventional Study
Refractory Auditory HallucinationsSchizophrenia
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
13 – 55
Sex
Any
Study type
Interventional
Purpose
Treatment
Participants needed
36 (estimated)
Sponsor
Shanghai Mental Health Center · Other
Who this trial is looking for
This trial is looking for people with schizophrenia who have ongoing auditory hallucinations despite treatment. Participants will receive a non-invasive treatment called rTMS, which targets areas in the brain based on special scans, while continuing their current medications.
Are You a Good Fit for This Trial?
You may be able to join if
I have been diagnosed with schizophrenia
I can use my right hand
I have finished primary school or more
I understand and can sign a consent form
I have ongoing auditory hallucinations despite treatment for at least 6 months
You may not be able to join if
I have had MECT treatment in the past 3 months
I have serious physical illnesses or brain injuries
I have metal implants in my body
I show aggressive behavior or threats to damage equipment
I have tattoos or dental implants inside my body
I have claustrophobia
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
This study is an before-after study in the same patient, which enrolled 36 psychiatric patients with refractory auditory hallucinations. The target of patient intervention relies on the results of magnetoencephalography localization. The medication and dosage remain unchanged during the intervention period. The investigators assume that the intervention targets for each auditory hallucination pati…
This study is an before-after study in the same patient, which enrolled 36 psychiatric patients with refractory auditory hallucinations. The target of patient intervention relies on the results of magnetoencephalography localization. The medication and dosage remain unchanged during the intervention period. The investigators assume that the intervention targets for each auditory hallucination patient are individualized.
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Eligibility Criteria
Inclusion Criteria:
* Clinical diagnosis of schizophrenia
* Must be able to right-handed
* Primary school education or above
* Understand and sign a written informed consent form (jointly signed by the guardian and the participant if under 18 years old)
* Existence of persistent auditory hallucinat…
Inclusion Criteria:
* Clinical diagnosis of schizophrenia
* Must be able to right-handed
* Primary school education or above
* Understand and sign a written informed consent form (jointly signed by the guardian and the participant if under 18 years old)
* Existence of persistent auditory hallucinations (defined as: taking sufficient antipsychotic medication for at least 6 months, combined with 3 antipsychotic medications still ineffective, and no significant improvement in auditory hallucinations symptoms, with an AHRS score still\>12)
Exclusion Criteria:
* MECT treatment within the past 3 months
* Major physical illnesses (organic lesions such as sensory and motor disorders, neurological disorders, and traumatic brain injury)
* Taboo symptoms for rTMS treatment (such as intracranial metal implants)
* Aggressive behavior and an impulse to damage equipment
* Metal (including orthodontic treatment, dental implants) and tattoos inside the body
* Claustrophobia
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