Albumin Assisted Diuresis in Patients with Cirrhosis and Ascites

Recruiting Phase 2 Interventional Study
Cirrhosis Ascites Hepatic
Prior Safety Data This treatment has already been tested in at least one earlier human trial.
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At a Glance
Age
18 and older
Sex
Any
Trial phase
Phase 2
Study type
Interventional
Purpose
Other
Participants needed
20 (estimated)
Sponsor
Anahita Rabiee MD MHS · Federal
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About This Trial

A small, pilot proof-of-concept placebo-controlled trial to explore the effects of albumin on diuresis in patients with cirrhosis, ascites and lower extremity edema. We will additionally investigate albumin's effect on preventing neurohumoral activation, and acute kidney injury after diuresis.

Trial Locations
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Eligibility Criteria
Inclusion Criteria: * Outpatient patients with decompensated cirrhosis with past or current ascites and persistent lower extremity edema despite oral diuretic titration * Serum albumin of \< 3.5 g/dL * Age \>=18 years old Exclusion Criteria: * Patients with GFR \< 30mL/min/1.73 m2 * Changes in or…
Contacts

Anahita Rabiee, MD, MHS

203-932-5711

anahita.rabiee@va.gov

CONTACT

Lynn F. Buchwalder, M.S.

203-932-5711

Lynn.Buchwalder@va.gov

CONTACT