No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
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At a Glance
Age
50 – 80
Sex
Any
Study type
Interventional
Purpose
Treatment
Participants needed
60 (estimated)
Sponsor
Oregon Health and Science University · Other
Who this trial is looking for
This trial is looking for people with Parkinson's disease who experience freezing of gait. Participants will engage in exercise sessions three times a week for six weeks and will be assessed before and after the program.
Are You a Good Fit for This Trial?
You may be able to join if
I have been diagnosed with Parkinson's disease
I experience freezing of gait
I am between 50 and 80 years old
I can follow directions and participate in exercise classes
I can commit to three exercise sessions per week for six weeks
I have bradykinesia and one or more related symptoms like tremor or rigidity
You may not be able to join if
I have a major musculoskeletal or neurological disorder
I have a recent acute illness affecting my health
I cannot engage in moderate-intensity exercise
I have a cognitive assessment score of 21 or lower
I use alcohol or recreational drugs excessively
I have had a recent change in medication
I cannot stand and walk for 2 minutes without help
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
The goals of this clinical trial are to 1) learn how two different rehabilitation interventions for PD can reduce Freezing of Gait (FOG) in people with Parkinson's disease, as assessed by patients, clinicians, and wearable sensors, and 2) to explore whether two different rehabilitation intervention can reduce FOG and improve daily life mobility in people with FOG sufficiently to justify a clinical…
The goals of this clinical trial are to 1) learn how two different rehabilitation interventions for PD can reduce Freezing of Gait (FOG) in people with Parkinson's disease, as assessed by patients, clinicians, and wearable sensors, and 2) to explore whether two different rehabilitation intervention can reduce FOG and improve daily life mobility in people with FOG sufficiently to justify a clinical trial.
Participants will:
* Be randomly assigned to one of two intervention groups (turning-focused agility exercise or strength-based exercise)
* Have one-on-one training sessions three times per week for 6 weeks
* Perform in-lab assessments before beginning and after completing the study intervention
* Use wearable mobility sensors during daily life to measure their walking and balance
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* diagnosis of idiopathic PD from movement disorders neurologist with the United Kingdom Brain Bank criteria of bradykinesia with one or more of the following - rest tremor, rigidity, and balance problems not from visual, vestibular, cerebellar or proprioceptive conditions
* rep…
Inclusion Criteria:
* diagnosis of idiopathic PD from movement disorders neurologist with the United Kingdom Brain Bank criteria of bradykinesia with one or more of the following - rest tremor, rigidity, and balance problems not from visual, vestibular, cerebellar or proprioceptive conditions
* reporting FOG in the New Freezing of Gait questionnaire (N-FOGQ)
* Hoehn \& Yahr stages II-IV
* ages 50-80 years old
* cognitive ability sufficient to participate in testing procedures and exercise classes
* be willing and able to participate in exercise intervention 3x/week for 6 weeks
Exclusion Criteria:
* Major musculoskeletal or neurological disorders, structural brain disease, epilepsy, acute illness or health history, other than PD, significantly affecting gait and turning (i.e., musculoskeletal disorder, vestibular problem, head injury, stroke, cardiac disease)
* medical condition or medications that precludes moderate-intensity exercise
* Montreal Cognitive Assessment (MoCA) ≤21 or inability to follow directions
* excessive use of alcohol or recreational drugs
* recent change in medication
* inability to stand and walk for 2 minutes without an assistive device
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