Manual Therapy in Hemophilic Arthropathy of the Ankle
Recruiting
N/AInterventional Study
Hemophilia A
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You do not need to have the condition being studied to take part.
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At a Glance
Age
18 – 65
Sex
Male
Study type
Interventional
Purpose
Treatment
Participants needed
13 (estimated)
Sponsor
Investigación en Hemofilia y Fisioterapia · Research network
Who this trial is looking for
This trial is looking for adults with hemophilia A or B who have issues with their ankle due to their condition. Participants will go through a therapy program involving manual techniques to help with pain and mobility.
Are You a Good Fit for This Trial?
Must be takingCoagulation factor VIIICoagulation factor FIX
You may be able to join if
I have been diagnosed with hemophilia A or B
I have severe hemophilia (less than 1% FVIII/FIX)
I am over 18 years old
I have a medical diagnosis of ankle arthropathy
I am on treatment with factor VIII or FIX concentrates
You may not be able to join if
I have neurological or cognitive disorders that affect my understanding
I did not sign the informed consent document
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
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Introduction: Haemophilic ankle arthropathy manifests as functional (deficit in muscle strength, mobility and proprioception), intra-articular degenerative alterations and chronic pain. Manual therapy techniques are characterised by treating the soft tissues with the aim of modifying their density, relieving pain, reducing tissue sensitivity and improving the ranges of mobility. The objective is t…
Introduction: Haemophilic ankle arthropathy manifests as functional (deficit in muscle strength, mobility and proprioception), intra-articular degenerative alterations and chronic pain. Manual therapy techniques are characterised by treating the soft tissues with the aim of modifying their density, relieving pain, reducing tissue sensitivity and improving the ranges of mobility. The objective is to evaluate the safety and effectiveness of a manual therapy protocol in patients with haemophilic ankle arthropathy.
Methods: Randomised crossover clinical trial. 13 patients with haemophilic ankle arthropathy from different regions of Spain will be recruited and randomised into two study groups (experimental and control). Each session of the experimental group will last 50 minutes, with 1 physiotherapy session per week for a period of 3 weeks. Patients will be evaluated at the beginning of the study, after the intervention and after a follow-up period of 4 weeks. The treatment programme includes 10 techniques that must be administered bilaterally. The study variables are the frequency of ankle haemarthrosis, range of movement, pressure pain threshold, pain intensity, joint status, biomechanical analysis of gait and balance, functionality and kinesiophobia.
Expected results: To evaluate the safety of manual therapy in patients with haemophilia. To observe changes in pain, mobility, joint condition, stability and functionality of the ankle, and kinesiophobia.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Patients diagnosed with haemophilia A and B
* With severe haemophilia phenotype (\<1% FVIII/FIX)
* Over 18 years of age
* With a medical diagnosis of ankle arthropathy and with clinical assessment using the Hemophilia Joint Health Score
* On prophylactic or on-demand treatment…
Inclusion Criteria:
* Patients diagnosed with haemophilia A and B
* With severe haemophilia phenotype (\<1% FVIII/FIX)
* Over 18 years of age
* With a medical diagnosis of ankle arthropathy and with clinical assessment using the Hemophilia Joint Health Score
* On prophylactic or on-demand treatment with coagulation factor VIII/FIX concentrates
Exclusion Criteria:
* Patients with neurological or cognitive disorders that prevent them from understanding the questionnaires and physical tests
* Failure to sign the informed consent document
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