Effects of Avocado on Blood Sugar and Hunger Signals
Avocado and Postprandial Responses
Recruiting
N/AInterventional Study
HealthyHealthy VolunteerHealthy VolunteersHealthy AdultHealthy Male and Female SubjectsHealthy SubjectsHealthy Volunteers OnlyHealthy Non-smokers
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
21 – 65
Sex
Any
Study type
Interventional
Purpose
Basic Science
Participants needed
30 (estimated)
Sponsor
University of Vermont Medical Center · Other
Who this trial is looking for
This trial is looking for healthy adults aged 21 to 65. Participants will try three different breakfast meals and see how they affect blood sugar and feelings of hunger and fullness after eating.
Are You a Good Fit for This Trial?
You may be able to join if
I am between 21 and 65 years old.
I have a body mass index (BMI) between 18.5 and 34.9.
You may not be able to join if
I am currently pregnant or breastfeeding.
I have been diagnosed with diabetes or prediabetes.
I have uncontrolled high blood pressure.
I have uncontrolled high cholesterol.
I have a history of kidney disease, liver disease, or certain cancers.
I smoke or have used tobacco in the last 6 months.
I have a serious eating disorder or food preferences that affect my diet.
I have lost more than 10% of my body weight in the last 6 months.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
The purpose of this study is to see how adding avocado to a breakfast meal affects blood sugar control and signals of hunger and fullness after eating.
The investigators will test the effects of 3 breakfast meals on blood sugar control and signals of hunger and fullness after eating:
1. Whole-wheat bread and strawberry jam
2. Whole-wheat bread, strawberry jam, and avocado
3. Whole-wheat bread an…
The purpose of this study is to see how adding avocado to a breakfast meal affects blood sugar control and signals of hunger and fullness after eating.
The investigators will test the effects of 3 breakfast meals on blood sugar control and signals of hunger and fullness after eating:
1. Whole-wheat bread and strawberry jam
2. Whole-wheat bread, strawberry jam, and avocado
3. Whole-wheat bread and strawberry jam (meal enriched with fat and fiber to mimic that of an avocado)
Participants will undergo 3 test periods, each separated by a week. Each test period consists of one day with set meals that the investigators will provide (breakfast, lunch, and dinner), and then the next morning, participants will eat a breakfast meal and have blood drawn several times over 4 hours.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Biological sex males or females
* Age 21 to 65 years
* BMI between 18.5 and 34.9 kg/m2
Exclusion Criteria:
* Actively pregnant or lactating women
* Diagnosis of prediabetes or diabetes (fasting glucose \>100 mg/dL)
* Current diagnosis of uncontrolled hypertension (systolic B…
Inclusion Criteria:
* Biological sex males or females
* Age 21 to 65 years
* BMI between 18.5 and 34.9 kg/m2
Exclusion Criteria:
* Actively pregnant or lactating women
* Diagnosis of prediabetes or diabetes (fasting glucose \>100 mg/dL)
* Current diagnosis of uncontrolled hypertension (systolic BP: \>160 mmHg, diastolic BP: \>95 mmHg), may receive treatment for hypertension as long as on a stable regimen for the previous one month
* Current diagnosis of uncontrolled hyperlipidemia (fasting total blood cholesterol \>200 mg/dL, fasting triglycerides \>200 mg/dL), may receive treatment for hyperlipidemia as long as on a stable regimen for the previous one month
* Presence of kidney disease, liver disease, hyperthyroidism, untreated or unstable hypothyroidism, certain cancers, gastrointestinal disease, pancreatic disease, other chronic metabolic diseases or malabsorption syndromes, HIV, or inflammatory conditions (such as arthritis, asthma, Crohn's disease, inflammatory bowel disease, gout, Lupus)
* History of bariatric or certain other surgeries related to weight control
* Any medication used to lower blood glucose/antidiabetic medications \[including, but not limited to metformin, sulfonylureas, glucagon-like peptide-1 (GLP-1) analogues, sodium-glucose cotransporter-2 (SGL2) inhibitors, thiazolidinediones, dipeptidyl peptidase (DPP)-IV inhibitors\] as well as medications affecting weight, appetite/hunger or gut motility.
* Smoking or use of other tobacco products (during 6 months prior to the start of the study)
* Antibiotic use during the intervention or for 3 weeks prior to any treatment period
* History of eating disorders or other significant food preferences that would interfere with the diet intervention (e.g., vegan lifestyle, very low-fat diets, high-protein diets)
* Allergies or adverse reactions to study foods (e.g., gluten intolerance), or food aversions that would interfere with diet adherence
* Body weight loss of \>10% within the last 6 months prior to study start
* Unable or unwilling to give informed consent or communicate with study staff
* Self-report of alcohol or substance abuse within the past 12 months and/or current acute treatment or rehabilitation program for these problems (long-term participation in Alcoholics Anonymous is not an exclusion)
* Other medical, psychiatric, or behavioral factors that in the judgment of the Principal Investigator may interfere with study participation or the ability to follow the intervention protocol
* Undergoing hormonal therapy of any kind, with the exception of a stable regime for the prior 6 months to study start.
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