DBS for Memory Problems After Traumatic Brain Injury
DBS for Cognitive Deficits After Traumatic Brain Injury
Recruiting
Phase 1
Interventional Study
TBI Traumatic Brain Injury
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
At a Glance
- Age
- 18 – 70
- Sex
- Any
- Trial phase
- Phase 1
- Study type
- Interventional
- Purpose
- Treatment
- Participants needed
- 10 (estimated)
- Sponsor
- Sunnybrook Health Sciences Centre · Other
Who this trial is looking for
This trial is looking for patients who have memory and thinking problems after a traumatic brain injury that haven’t improved with standard treatments. Participants may undergo a surgical therapy called deep brain stimulation (DBS) to see if it can help improve their symptoms.
Are You a Good Fit for This Trial?
You may be able to join if
- I am between 18 and 70 years old.
- I have been diagnosed with memory and cognitive deficits after a TBI.
- I have cognitive disorder, dementia, or amnestic disorder due to TBI.
- I score at least 1.5 standard deviations below my estimated normal intelligence on memory tests.
- I have had a traumatic brain injury for at least 1 year and no longer respond to donepezil or other therapies.
- I can give my informed consent and keep up with appointments.
You may not be able to join if
- I have an active neurologic disease like epilepsy or Alzheimer's.
- I can't have an MRI for any reason.
- I have conditions that could increase risks during surgery.
- I currently have thoughts of suicide or harming others.
- I am pregnant.
- I am likely to move during the year of the study.
- I have kidney problems.
Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
Check Your Eligibility
About This Trial
Patients with memory and cognitive deficits following TBI that do not respond to conventional treatments experience a decrease in quality of life. Despite advances in neuroimaging, genetics, pharmacology and psychosocial interventions in the last half century, little progress has been made in altering the natural history of the condition or its outcome.
This study would explore whether a surgical…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
1. Female or male patients between age 18-70.
2. Diagnosis of memory and cognitive deficits in patients who suffered TBI will be defined according to the Diagnostic and Statistical Manual 5th edition (DSM-5).
3. Patients with cognitive disorder not otherwise specified, dementia,…
Contacts