ARTEMIS-102: HS-20093 Combinations in Patients with Advanced Metastatic Colorectal Cancer

Inclusion Criteria: * At least age of 18 years at screening. * Histologically or cytologically confirmed, locally advanced or metastatic colorectal cancer. 1. Dose escalation part will enroll advanced metastatic colorectal cancer patients who have progressed on or intolerant to standard therapies. 2. Dose expansion part will enroll advanced metastatic colorectal cancer patients who have not received prior treatment for advanced/metastatic colorectal cancer. * At least one measurable lesion according to RECIST 1.1. * Eastern Cooperative Oncology Group (ECOG) Performance Status of 0\~1. * Life expectancy \>= 12 weeks. * Men or women should be using adequate contraceptive measures throughout the study. * Females subjects must not be pregnant at screening or have evidence of non-childbearing potential. * Signed and dated Informed Consent Form. Exclusion Criteria: * Treatment with any of the following: 1. Previous or current treatment with B7-H3 targeted therapy or ADCs with topoisomerase I inhibitors as the payload 2. Any cytotoxic chemotherapy, investigational agents and small molecule targeted therapy within 14 days prior to the first scheduled dose of HS-20093 3. Prior treatment with macromolecule anti-tumor therapy or other anticancer drugs within 28 days prior to the first scheduled dose of HS-20093 4. Radiotherapy with a limited field of radiation for palliation within 2 weeks, or patients received more than 30% of the bone marrow irradiation, or large-scale radiotherapy within 4 weeks prior to the first scheduled dose of HS-20093 5. Pleural or peritoneal effusion requiring clinical intervention. Pericardial effusion 6. Major surgery within 4 weeks of the first dose of HS-20093 7. Spinal cord compression or brain metastases. 8. Treatment with drugs that are predominantly CYP3A4 strong inhibitors or inducers or sensitive substrates of CYP3A4 with a narrow therapeutic range within 7 days of the first dose of study drug; or requiring treatment with these drugs during the study. 9. Currently receiving drugs known to prolong QT interval or may cause torsade de pointe; or requiring treatment with these drugs during the study. * Any unresolved toxicities from prior therapy greater than Grade 2 according to Common Terminology Criteria for Adverse Events (CTCAE) 5.0 with the exception of stable hypothyroidism treated with hormone replacement therapy, alopecia or neurotoxicity. * History of other primary malignancies. * Inadequate bone marrow reserve or organ dysfunction * Evidence of cardiovascular risk. * Severe, uncontrolled or active cardiovascular diseases. * Diabetes ketoacidosis or hyperglycemia hypertonic occurring within 6 months before the first dose of the study drug. * Severe or poorly controlled hypertension. * Bleeding symptoms with apparent clinical significance or obvious bleeding tendency within 1 months prior to the first dose of HS-20093 * Serious arteriovenous thrombosis events occurred within 3 months before the first dose. * Severe infections occurred within 4 weeks before the first dose. * Patients who have received continuous steroid treatment for more than 30 days within 30 days before the first dose, or need long-term (≥ 30 days) steroid treatment, or who have other acquired and congenital immunodeficiency diseases, or have a history of organ transplantation * The presence of active infectious diseases has been known before the first dose such as hepatitis B, hepatitis C, tuberculosis, syphilis, or human immunodeficiency virus HIV infection, etc. * Hepatic encephalopathy, hepatorenal syndrome, or Child-Pugh Grade B or more severe cirrhosis. * Other moderate or severe lung diseases that may interfere with the detection or treatment of drug-related pulmonary toxicity or may seriously affect respiratory function. * Previous history of serious neurological or mental disorders, including epilepsy, dementia or severe depression and any other status that may interfere in assessment. * Women who are breastfeeding or pregnant or planned to be pregnant during the study period. 18\. Vaccination or hypersensitivity of any level within 4 weeks prior to the first dose of HS-20093 * History of severe hypersensitivity reaction, severe infusion reaction or allergy to recombinant human or mouse derived proteins. * Hypersensitivity to any ingredient of HS-20093. * Unlikely to comply with study procedures, restrictions, and requirements in the opinion of the investigator * Any disease or condition that, in the opinion of the investigator, would compromise subject safety or interfere with study assessments