Close Loop Smart Weaning for INO With PPHN

Inclusion Criteria: 1. The administration of inhaled nitric oxide (iNO) has commenced or is anticipated to commence for a duration of 24 hours or more, based on a clinical diagnosis of persistent pulmonary hypertension of the newborn (PPHN); 2. There is a demonstrable positive response to iNO treatment; 3. The iNO delivery system employed is appropriate and meets the conditional requirements, featuring an intelligent closed-loop offline functionality; 4. The guardian or legal representative possesses a comprehensive understanding of the potential benefits and risks associated with participation in this study and has expressed a willingness to consent by signing the informed consent document. Exclusion Criteria: 1. There are established contraindications associated with the use of nitric oxide, which include the following conditions: 1. Severe hypoplasia of the left heart or duct-dependent congenital heart disease; 2. Life-threatening congenital anomalies and congestive heart failure; 3. Congenital methemoglobinemia; 4. Significant hemorrhagic events, such as intracranial hemorrhage, intraventricular hemorrhage, and pulmonary hemorrhage. 2. Patients with chronic pulmonary conditions and other refractory diseases are not permitted to initiate withdrawal from the inhaled nitric oxide (iNO) treatment within a seven-day period following its administration. 3. In cases where there is no observable response to iNO or if the duration of use is less than 30 minutes, a strict tapering protocol for withdrawal is not required. 4. If the concentration of iNO treatment exceeds 20 parts per million (ppm) during the initiation phase or if the starting concentration for withdrawal is below 20 ppm, specific considerations must be taken into account. 5. Participation in concurrent clinical trials involving other pharmacological agents or medical devices is prohibited. 6. The investigator may determine that participation in this study is not appropriate for certain individuals.