Prophylactic Anti-aRrhythmic Therapy With Amiodarone in Critically Ill Patients Admitted for an Out-of-hospital Cardiac Arrest With Initial Shockable Rhythm

Inclusion Criteria: 1. Patient aged ≥ 18 years 2. Admitted in intensive care unit 3. Out-of-hospital cardiac arrest with initial shockable rhythm 4. Presumed cardiac or unknown cause 5. Delay between ROSC and screening for randomisation \< 6 hours 6. Informed consent from the patient or a surrogate or deferred consent 7. Affiliated to or benefiting from a social insurance Exclusion Criteria: 1. Cardiac arrest secondary to an extra-cardiac cause (suspected or confirmed) 2. Indication for amiodarone decided by the physician at ICU admission 3. No central venous catheter available for continuous infusion of amidoarone 4. Thyroid disease under treatment 5. History of cardiac conduction disorders, not treated by permanent pacemaker 6. Any contra indication to amiodarone treatment 7. Refractory ventricular arrhythmia or electrical storm 8. Need for veno-arterial extracorporeal membrane oxygenation (VA-ECMO) at admission 9. Known limitations in therapy and Do Not Resuscitate-order 10. Moribund patient due to pre-arrest history (estimated life expectancy \< 3 months) 11. Pregnant or breastfeeding women 12. Patient needing a nadolol treatment due to QT long syndrome or catecholaminergic polymorphic ventricular tachycardia 13. Patient with known pulmonary fibrosis 14. Patient with known interstitial lung disease