Volatility in Paranoia (VIP) Trial: An RCT of Changes in Volatility With Psychotherapy
Recruiting
N/A
Interventional Study
Schizophrenia Disorders
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
At a Glance
- Age
- 18 – 65
- Sex
- Any
- Study type
- Interventional
- Purpose
- Basic Science
- Participants needed
- 120 (estimated)
- Sponsor
- Vanderbilt University Medical Center · Other
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About This Trial
The goal of this clinical trial is to learn whether learning and belief updating change in response to the treatment of persecutory delusions, in individuals with schizophrenia-spectrum disorders.
The main questions are:
1. do prior expectations about environmental volatility reduce following effective psychotherapeutic treatment of delusions?
2. does corresponding brain activity related to vola…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Men and women age 18 - 65.
* Communicative in English.
* Premorbid IQ \>79 (WTAR)
* Provide voluntary, written informed consent.
* Stable medication regimen over at least the past two weeks, including the use of either an oral or intramuscular administration of an antipsychoti…
Contacts