Sonrotoclax, Rituximab, and Zanubrutinib in Treating Participants With Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, and Mantle Cell Lymphoma

Recruiting Phase 2 Interventional Study
Chronic Lymphocytic Leukemia Mantle Cell Lymphoma Recurrent Chronic Lymphocytic Leukemia Recurrent Mantle Cell Lymphoma Recurrent Small Lymphocytic Lymphoma Refractory Chronic Lymphocytic Leukemia Refractory Mantle Cell Lymphoma Refractory Small Lymphocytic Lymphoma Small Lymphocytic Lymphoma
No Placebo Group Every participant receives an active treatment — no one gets a placebo. Prior Safety Data This treatment has already been tested in at least one earlier human trial.
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At a Glance
Age
18 and older
Sex
Any
Trial phase
Phase 2
Study type
Interventional
Purpose
Treatment
Participants needed
30 (estimated)
Sponsor
Fred Hutchinson Cancer Center · Other
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About This Trial
This phase II trial studies the side effects of an escalated ramp-up of sonrotoclax following initial debulking with zanubrutinib or rituximab in treating patients with chronic lymphocytic leukemia (CLL), small lymphocytic lymphoma (SLL), and mantle cell lymphoma (MCL) that is newly diagnosed, has come back after a period of improvement (relapsed) or does not respond to treatment (refractory). Rit…
Trial Locations
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Eligibility Criteria
Inclusion Criteria: * Provision of signed and dated written informed consent prior to any study-specific procedures, sampling, or analyses * Age 18 years or older * Confirmed diagnosis (per World Health Organization \[WHO\] guidelines, unless otherwise noted) of one of the following: * CLL/SLL C…
Contacts

Mazyar Shadman, MD, MPH

206-667-5467

mshadman@fredhutch.org

CONTACT