Fertility Enhancement Through Regenerative Treatment in Ovaries and Testes

Male patients: * Male patients aged 20 to 50 years. * Diagnosed with testicular failure (low testosterone) or hypogonadism (impaired gonadal function), or azoospermia (no sperm in ejaculate) * Suboptimal response to conventional treatments, such as testosterone replacement therapy (TRT) or fertility-enhancing medications (Clomiphene citrate or anastrozole). * General good health without significant contraindications to stem cell or stem cell-derived exosome therapy. * Willing and able to provide informed consent and comply with the study protocol. * Patients who have been evaluated for testicular failure and are seeking further treatment. Female patients: * Female patients aged 20 to 50 years. * Diagnosed with premature ovarian failure (POF) or ovarian insufficiency, confirmed through clinical, hormonal, and imaging assessments. * Failure or suboptimal response to conventional treatments, such as hormone therapy. * General good health without significant contraindications to stem cell or stem cell-derived exosome therapy. * Willing and able to provide informed consent and comply with the study protocol. * Patients who have been evaluated for ovarian failure are seeking further treatment. Exclusion criteria * Severe comorbid conditions, such as advanced cardiovascular disease, renal failure, or uncontrolled diabetes. * Active malignancies or history of cancer within the past 5 years. * Active infections or systemic inflammatory conditions. * History of testicular surgery or trauma that could interfere with the study outcomes. * Use of anticoagulants or medications that may contraindicate stem cell or stem cell-derived exosome therapy. * Participation in another investigational drug or treatment study within the past 6 months. * Contraindications to stem cell or stem cell-derived exosome therapy, such as immune deficiencies or allergies to any treatment components. * Severe neurological disorders or cognitive impairment may limit the ability to provide informed consent or follow study instructions. * Any condition that, in the investigator's opinion, could interfere with the study or pose an undue risk to the patient. * Women with a primary diagnosis of psychogenic ovarian dysfunction or infertility. * History of ovarian surgery or trauma that could interfere with the study outcomes.