A.I and Machine Learning Based Risk Prediction Model to Improve the Clinical Management of Endometrial Cancer.
Recruiting
Observational Study
Endometrium Cancer
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
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At a Glance
Age
18 and older
Sex
Female
Study type
Observational
Participants needed
40 (estimated)
Sponsor
Regina Elena Cancer Institute · Other
Who this trial is looking for
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Prediction of preoperative endometrial biopsy: the evolution from hyperplasia to cancer, the prognosis and the risk of recurrence. Intelligence methods artificial risk will be used to redefine the current risk classes including our profile immuno-mutational to provide a more precise characterization and closer to the real prognosis of the patient.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Age \> 18 years;
* Histological diagnosis of endometrial hyperplasia, endometrioid adenocarcinoma of the endometrium, healthy endometrium in patients undergoing total hysterectomy for benign extra-endometrial disease;
* Written informed consent (to the study and data processin…
Inclusion Criteria:
* Age \> 18 years;
* Histological diagnosis of endometrial hyperplasia, endometrioid adenocarcinoma of the endometrium, healthy endometrium in patients undergoing total hysterectomy for benign extra-endometrial disease;
* Written informed consent (to the study and data processing), for the party's patients only prospective and/or in follow-up) For the retrospective cohort: availability of samples adequately stored at the biobank of the Institute and availability of data relating to follow-up (at least 2 years)
Exclusion Criteria:
All exclusion criteria adopted in the surgical protocols will be applied to the study. In particular:
* Comorbidities not controlled with adequate medical therapy;
* Infections of the endometrial cavity (pyometra);
* Synchronous cancer;
* Neoadjuvant treatments;
* Previous radiotherapy treatments of the pelvic region;
* Hormone therapies.
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