The NUTRIOME Study - a Data-driven Precision Nutrition Intervention

Inclusion Criteria: * Men and women * Age 40 to 70 years * Body mass index (BMI) 27-35 kg/m2 * Signed informed consent Exclusion Criteria: * History of diagnosed cardiovascular disease (e.g. stroke, heart disease) * Diagnosed type 1 or type 2 diabetes * Finger prick glucose test at screening indicating diabetes (fasting \>6.9 mmol/L; non-fasting \>11.0 mmol/L) * Antibiotic use in the last 3 months * Taking medication that can interfere with the planned outcome measures, as judged by the study physician (e.g. peroxisome proliferator-activated receptor-α \[PPAR-α\] or PPAR-γ agonists \[fibrates\], sulfonylureas, biguanides, α-glucosidase inhibitors, thiazolidinediones, repaglinide, nateglinide and insulin, chronic use of NSAIDs). Statins and hypertension medication are allowed if the medication regimen has been stable for the last three months * Stomach and gastrointestinal conditions (e.g. Morbus Chron, Ulcerative colitis, irritable bowel syndrome, malabsorption, colostomy, bowel resection, gastric bypass surgery etc.) * History of major gastrointestinal surgery * Anaemia: Hb concentrations \< 8.5 mmol/L for men and \< 7.5 mmol/L for women * Recent blood donation (within 2 months prior to the screening) * Recent participation in another intervention study (within 2 months prior to the screening) * Allergy or intolerance to medical skin adhesives * Chronic or acute inflammatory conditions (e.g., rheumatoid arthritis, psoriatic arthritis) * Autoimmune disorders * Thyroid disorders * Significant renal or liver dysfunction or chronic kidney or liver disease * Known food allergies/intolerances to intervention foods or food products used in the study * Following specific dietary regimen that could impact results or not suitable for the study design (e.g. vegetarian, vegan) * Habitual tobacco consumption (e.g. smoking, use of snus, vaping) * Alcohol intake ≥ 14 alcoholic beverages/week for women and ≥ 21 alcoholic beverages/week for men * Current or planned pregnancy or lactating * Other serious medical conditions that could interfere with participation or study outcomes * Unable to sufficiently understand written and spoken national language (where the study centre is located) to provide written consent and understand information and instructions from the study personnel. * Deemed unsuitable for participation in the trial, for any reason, as judged by the research physician or PI. * Working at the division conducting the trial at any of the three study centres. * Do not have a mobile phone that is suitable for the use of a research app.