No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
21 – 75
Sex
Any
Study type
Interventional
Purpose
Basic Science
Participants needed
36 (estimated)
Sponsor
University of Minnesota · Other
Who this trial is looking for
This trial is looking for people with Parkinson's disease, especially those who experience freezing of gait. Participants will be involved in experiments that examine electrical signals while moving or during freezing events.
Are You a Good Fit for This Trial?
You may be able to join if
I have been diagnosed with Parkinson's disease.
I am between 21 and 75 years old.
I can walk 50 meters without help.
I have a Medtronic Percept device implanted.
It has been at least 3 months since my device was activated.
I belong to a socially disadvantaged group.
I am an active member of the military or a Department of Defense employee.
You may not be able to join if
I have a diagnosis of dementia with Lewy bodies or Alzheimer's disease.
I have a history of seizures or other significant neurological disorders.
I have musculoskeletal issues that affect my walking.
I have neck or back muscle conditions that impact my movement.
I have visual or balance problems that might affect my participation.
I cannot give consent due to reduced capacity.
I am currently pregnant.
I have post-operative complications affecting my safety.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
The purpose of this research is to examine the possible causes and signs of freezing of gait (FOG) secondary to Parkinson's disease (PD). To achieve this, the study will use the novel (on-label and FDA-approved) local field potential (LFP) measuring capability of the Medtronic Percept™ deep brain stimulation (DBS) system to compare oscillatory activity in people who have Parkinson's disease, with …
The purpose of this research is to examine the possible causes and signs of freezing of gait (FOG) secondary to Parkinson's disease (PD). To achieve this, the study will use the novel (on-label and FDA-approved) local field potential (LFP) measuring capability of the Medtronic Percept™ deep brain stimulation (DBS) system to compare oscillatory activity in people who have Parkinson's disease, with and without freezing of gait (FOG). This will be conducted as three separate experiments, participants may volunteer for one or more experiments:
Experiment 1: The first experiment will compare LFPs during gait initiation with and without a cue, in people with (PD+FOG) and without FOG (PD-FOG).
Experiment 2: The second experiment will compare LFPs during the successful movement transitions vs. freezing-events during a FOG provocation course in people with FOG.
Experiment 3: The third experiment will compare LFPs during rapid alternating movements of the wrist and/or foot, in people with and without FOG
Trial Locations
Loading…
Loading trial locations…
Facility
City
State
Country
Status
Eligibility Criteria
Inclusion Criteria:
* Diagnosis of idiopathic PD.
* Age 21-75 (see Inclusion of Individuals across the Lifespan for justification of age range).
* Able to ambulate independently without the use of an assistive device (e.g. cane) for 50 meters.
* Implanted Medtronic Percept TM Device.
* At least 3 m…
Inclusion Criteria:
* Diagnosis of idiopathic PD.
* Age 21-75 (see Inclusion of Individuals across the Lifespan for justification of age range).
* Able to ambulate independently without the use of an assistive device (e.g. cane) for 50 meters.
* Implanted Medtronic Percept TM Device.
* At least 3 months since the initial activation of the neurostimulator.
* Undervalued, under-represented, or disenfranchised social group may be included.
* Active members of the military (service members), DoD personnel (including civilian employees) may be included.
* Individual or group that is disadvantaged in the distribution of social goods and services such as income, housing, or healthcare may be included.
Exclusion Criteria:
* Meet criteria for dementia with Lewy bodies, Multiple Systems Atrophy, Alzheimer's disease, or other neurodegenerative disorder.
* History of seizures or other significant neurological disorders that may affect participation or performance in the study.
* History of musculoskeletal disorders that significantly affect walking or movement of limb(s) that would affect the participation in the experimental task (Participants will be excluded from that task, but may participate in other tasks, for example, may be excluded from Experiment 1 if the disorder affects walking, but may still participate in Experiment 3).
* History of muscular conditions of the neck and back, including whiplash that would affect walking experiments.
* History of visual and/or vestibular conditions that may affect participation or performance in the study.
* Reduced capacity to consent. This will be assessed using a 2-stage process. Initially, participants will be tested using the University of California, San Diego, Brief Assessment of Capacity to Consent (UBACC). If concerns are raised from the UBACC test, the individual will be further tested using the MacArthur Competency Assessment Tool.
* Pregnant people.
* Post-operative complications or adverse effects (e.g. ON stimulation dystonia) that affect patient safety or confound the experiment.
Picking one helps us show the most relevant trials first.
Your results are loading in the background — you can
change this any time from the results page.
Set your location to continue
Find My Trials uses your location to surface clinical trials near you.
Add your city or zip code to your profile and try again.