The Prism Conformity Trial for Post-Traumatic Stress Disorder in Adolescents

Inclusion Criteria: 1. Ages 12 to 21 years. 2. Any gender. 3. Diagnosis of PTSD, established according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-V). 4. ≥1 year since index trauma. 5. For candidate participants under 18 years old: Willingness and ability to provide assent, with the participant's legal guardian able and willing to provide informed consent for their study participation. 6. For candidate participants 18 years old and above: Willingness and ability to provide informed consent for their study participation. 7. English speaking, writing and reading. 8. Normal or corrected-to-normal vision and hearing. Exclusion Criteria: 1. Have completed one or more full courses of trauma-focused therapy in the past (i.e., Eye Movement Desensitization and Reprocessing \[EMDR\], Prolong Exposure Therapy etc.), eligibility will be deemed upon the clinical judgement of the investigator. 2. Diagnosis for schizophrenia, schizoaffective disorder, schizophreniform disorder, Bipolar I disorder, or delusional disorder. 3. Any mood or anxiety disorder as defined by the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5), that has been the primary focus of mental health treatment within the 6 months prior to screening, based on the clinical judgment of the site investigator. 4. Diagnosis of autism spectrum requiring substantial support, intellectual disability of mild severity at discretion of investigator. 5. Diagnosis of moderate or severe substance use disorder within the last 3 months of the screening visit (as defined in DSM-5-substance use disorder) or at the screening visit. 6. Current symptom level of moderate or severe ADHD (as defined in DSM-5 ADHD disorder) or at screening visit. 7. Any change in- or initiation of- psychotropic medications within the past 4 weeks. At the time of recruitment, subjects must have no intention of changing their medication or psychotherapy during the study duration. 8. Any suicidal behavior within the past 1 year (i.e., actual attempt, interrupted attempt, aborted attempt, or preparatory acts or behavior), prior to screening and during the screening period. 9. Recent initiation (within the past 3 months) of cognitive-behavioral therapy or any evidence-based PTSD psychotherapy (Cognitive Processing Therapy \[CPT\], Prolonged Exposure \[PE\], Eye Movement Desensitization and Reprocessing \[EMDR\]). However, continuation of established maintenance supportive therapy will be permitted. 10. Any history of brain surgery, of penetrating, neurovascular, infectious, or other major brain injury, of epilepsy, or of other major neurological abnormality (including a history of traumatic brain injury \[TBI\] with loss of consciousness for more than 24 hours or posttraumatic amnesia for more than 7 days). 11. Any unstable medical condition, as per the clinical judgement of the investigator. 12. Enrollment in another interventional clinical study at screening or within 2 months prior to screening or intended enrollment within the duration of this study. 13. Female subjects who are pregnant, nursing, or who plan to become pregnant while in the trial.