The Effect of Discontinuation of Renin Angiotensin System Inhibitors on the Perioperative Myocardial Injury in Adult Patients Undergoing Colorectal Cancer Surgery
Recruiting
Phase 3
Interventional Study
Myocardium; Injury
Perioperative/Postoperative Complications
Angiotensin-Converting-Enzyme Inhibitor
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Pivotal Trial
This treatment is in the last trial phase before FDA approval.
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
At a Glance
- Age
- 18 – 70
- Sex
- Any
- Trial phase
- Phase 3
- Study type
- Interventional
- Purpose
- Prevention
- Participants needed
- 156 (estimated)
- Sponsor
- Kasr El Aini Hospital · Other
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About This Trial
The aim of this study is to estimate the effect of discontinuation of RAS inhibitors on myocardial injury in cancer patients undergoing major abdominal surgeries.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Age \> 18 years
* Both sexes
* ASA 2-3
* Chronic hypertensive patients (\> 3 months before surgery) controlled on ACEIs or ARBs or combination therapy containing one of the RAS inhibitors.
* Scheduled for major abdominal cancer surgery (surgery with an expected duration of \> …
Contacts