Probiotics for Chronic Kidney Disease Progression
Probiotic Supplementation and Disease Progression in CKD: A Randomized Trial
Recruiting
Phase 1
Phase 2
Interventional Study
Kidney Disease, Chronic
Renal Insufficiency, Chronic
Gut Dysbiosis
Uremic Toxins
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
At a Glance
- Age
- 18 and older
- Sex
- Any
- Trial phase
- Phase 1/2
- Study type
- Interventional
- Purpose
- Prevention
- Participants needed
- 72 (estimated)
- Sponsor
- Mansoura University · Other
Who this trial is looking for
This trial is looking for adults with moderate to severe chronic kidney disease. Participants will take either probiotics or a placebo for 6 months and attend check-ups to monitor their kidney health and any side effects.
Are You a Good Fit for This Trial?
You may be able to join if
- I am 18 years or older.
- I have been diagnosed with Chronic Kidney Disease Stage III or IV.
- I am in stable health with no recent serious illnesses.
- I am not currently taking probiotics or prebiotics.
- I am willing to provide informed consent.
- I can attend all required clinic visits and provide samples.
You may not be able to join if
- I have CKD Stage I, II, or V, or I am on dialysis.
- I am currently using probiotics or prebiotics.
- I have a history of active cancer or am undergoing chemotherapy.
- I have significant gastrointestinal disease.
- I am pregnant or breastfeeding.
- I have an autoimmune disease.
- I take long-term antibiotics or anti-inflammatory medications.
- I have severe behavioral or cognitive disorders.
Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.
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About This Trial
The goal of this clinical trial is to learn whether probiotic supplementation can slow disease progression in patients with moderate to severe chronic kidney disease (CKD). The trial will also assess the safety of probiotics in these patients.
The main questions the study aims to answer are:
Does probiotic supplementation improve kidney function by reducing serum creatinine levels and protein in…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Adults aged ≥ 18 years (both males and females).
* Diagnosed with Chronic Kidney Disease (CKD) Stage III or IV, confirmed by eGFR.
* Stable medical condition with no recent hospitalization for acute kidney injury or other serious illnesses.
* Not currently on probiotic supplem…
Contacts