A Simple Breath Test to Detect Liver Cancer and Monitor Liver Conditions
Recruiting
Observational Study
Liver Cirrhosis
Hepatocellular Carcinoma (HCC)
Cholangiocarcinoma
Cholangitis, Sclerosing
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
At a Glance
- Age
- 18 and older
- Sex
- Any
- Study type
- Observational
- Participants needed
- 750 (estimated)
- Sponsor
- Imperial College London · Other
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About This Trial
Liver cancer is often diagnosed too late for effective treatment. The VOCAL2 study is developing a simple, non-invasive breath test to help detect liver cancer earlier and monitor liver conditions like cirrhosis. The test analyzes tiny chemicals in exhaled breath called volatile organic compounds (VOCs) to identify signs of liver disease.
Who can take part?
Adults aged 18 or older who:
Have liv…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Males and females
* Adult participants ≥ 18 years old
* Participants with either:
1. Histologically or radiologically-confirmed\* hepatocellular carcinoma or cholangiocarcinoma (participants with liver cancer)
2. Liver cirrhosis, confirmed on imaging or histology from bio…
Contacts