FGFR4 Chimeric Antigen Receptor (CAR) T Cells in Children and Young Adults With Recurrent or Refractory Rhabdomyosarcoma

Recruiting Phase 1 Interventional Study
Rhabdomyosarcoma
No Placebo Group Every participant receives an active treatment — no one gets a placebo.
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At a Glance
Age
3 – 39
Sex
Any
Trial phase
Phase 1
Study type
Interventional
Purpose
Treatment
Participants needed
50 (estimated)
Sponsor
National Cancer Institute (NCI) · NIH
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About This Trial
Background: Rhabdomyosarcoma (RMS) is a cancer of soft tissues. It is the most common soft tissue sarcoma seen in children. RMS cancer cells have a protein called FGFR4 on their surface. Researchers want to try a new kind of treatment for RMS: They will collect a person s own T cells, a type of immune cell; then they will change the T cells so they are better able to target the FGFR4 protein and …
Trial Locations
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Eligibility Criteria
* INCLUSION CRITERIA * Histologically confirmed rhabdomyosarcoma by the NCI Department of Pathology. Note: Since FGFR4 expression is universal in rhabdomyosarcoma, confirmation of FGFR4 expression is not required. * Relapsed or refractory rhabdomyosarcoma after at least two (2) cancer treatment re…
Contacts

NCI POB Solid Tumor Referral Team

(240) 858-7013

ncipobstreferrals@mail.nih.gov

CONTACT

Srivandana Akshintala, M.D.

(240) 858-3448

srivandana.akshintala@nih.gov

CONTACT