Involvement of the Septal Nuclei of the Human Brain in Alcohol Use Disorder
Recruiting
N/A
Interventional Study
Alcohol Use Disorder
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
At a Glance
- Age
- 30 – 65
- Sex
- Any
- Study type
- Interventional
- Purpose
- Basic Science
- Participants needed
- 25 (estimated)
- Sponsor
- Anders Fink-Jensen, MD, DMSci · Other
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About This Trial
Alcohol activates reward systems in different brain areas, i.e., the nucleus accumbens, dorsal striatum, extended amygdala, and prefrontal cortex. These areas are all part of the reward neurocircuitry, which plays an important role in the development of addiction.
A former study performed on rodents has shown that a specific area of the forebrain, the septal nuclei, is associated with the feeling…
Trial Locations
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Eligibility Criteria
Inclusion criteria:
* Diagnosed with alcohol use disorder (AUD) according to DSM-5, and alcohol dependence according to ICD-10
* An Alcohol Use Disorder Identification Test (AUDIT) score ≥ 15
* At least six heavy drinking days for the last 30 days, measured with the Time Line Follow Back (TLFB) met…
Contacts