Effects of Exogenous Ketosis on Proteinuria and Renal Function
Recruiting
N/A
Interventional Study
Renal Insufficiency, Chronic
Polycystic Kidney Diseases
Proteinuria
Ketosis
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
At a Glance
- Age
- 18 and older
- Sex
- Any
- Study type
- Interventional
- Purpose
- Prevention
- Participants needed
- 43 (estimated)
- Sponsor
- Gødstrup Hospital · Other
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About This Trial
A randomized, placebo-controlled, double-blinded crossover study will be conducted. Fourteen patients with polycystic kidney disease (PKD) and 29 patients with proteinuric kidney disease will receive ketone bodies (Ketone-IQ) and placebo in a randomized order. Each treatment period is four weeks. There will be a wash-out period of two weeks in between treatment periods. Effect variables will be me…
Trial Locations
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Eligibility Criteria
Inclusion Criteria
Study A (patients with CKD):
* ACR \> 200 mg/g \<3000 mg/g
* eGFR \>30 ml/min/1,73m2
* Treatment with Renin-Angiotension System (RAS) blockers and SGLT-2 inhibitors for a minimum of 4 weeks prior to inclusion
* Safe contraception if women in childbearing age
Study B (patients w…
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