Mitochondrial Function and Metabolomic Profile in Alzheimer's Disease and Related Dementias
Recruiting
N/AInterventional Study
Alzheimer Disease
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
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Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 and older
Sex
Any
Study type
Interventional
Purpose
Basic Science
Participants needed
250 (estimated)
Sponsor
Centre Hospitalier Universitaire de Nice · Other
Who this trial is looking for
This trial is looking for people with Alzheimer's disease or related memory issues, as well as healthy volunteers. Participants will provide samples and undergo tests to help researchers understand how these conditions affect cell function.
Are You a Good Fit for This Trial?
You may be able to join if
I have a neurocognitive disorder for at least 6 months
I have given my consent to participate
I am part of a social security scheme
I have been diagnosed with Alzheimer's disease
I have been diagnosed with a mild or major neurocognitive disorder
I have no memory issues if I am a healthy volunteer
I am an adult
You may not be able to join if
I am considered a vulnerable person
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
This project aims to study on one hand the early mitochondrial alterations, common or specific, occurring in peripheral cells of patients with Alzheimer's disease or related dementia and, on the other hand, identify the metabolomic biomarkers that may be at the origin of mitochondrial disturbances associated with the disease. This will be the first study combining functional analyses of mitochondr…
This project aims to study on one hand the early mitochondrial alterations, common or specific, occurring in peripheral cells of patients with Alzheimer's disease or related dementia and, on the other hand, identify the metabolomic biomarkers that may be at the origin of mitochondrial disturbances associated with the disease. This will be the first study combining functional analyses of mitochondria and exploratory metabolomic assessments in the same cohort at early stages of the disease.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Neurocognitive disorder with spontaneous complaint or reported for at least 6 months
* Diagnostic process according to current Haute Autorité de Santé (HAS) recommendations.
* cerebrospinal fluid biomarker dosage done within the study center and agreement to bio-collection of …
Inclusion Criteria:
* Neurocognitive disorder with spontaneous complaint or reported for at least 6 months
* Diagnostic process according to current Haute Autorité de Santé (HAS) recommendations.
* cerebrospinal fluid biomarker dosage done within the study center and agreement to bio-collection of residual cerebrospinal fluid
* Patient having agreed to sign the informed consent
* Patient affiliated or beneficiary of a social security scheme
For alzheimer group : diagnosis of Alzheimer's disease according to NIA-AA 2024 criteria (presence of a pathogenic amyloid process in the cerebrospinal fluid)
For non alzheimer group : diagnosis of mild or major neurocognitive disorder according to Manuel diagnostique et statistique des troubles mentaux edition 5 (DSM-V) criteria, not linked to Alzheimer's disease (absence of pathogenic amyloid process in the cerebrospinal fluid)
For healthy volonteers:
* Adult patients
* No history of neurological or psychiatric disorders
* No complaints of memory problems or cognitive impairment
* Mini-Mental State Examination (MMSE) score ≥ 27/30
* Clinical Dementia Rating - Sum of Boxes (CDR-SOB) equal to 0
* Patient affiliated with or covered by a social security scheme
Exclusion Criteria:
\- Vulnerable people
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