Butyric Acid Supplementation for Gut Improvement After Cardiac Surgery in Kids
Recruiting
Phase 1
Phase 2
Interventional Study
Congenital Heart Disease (CHD)
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
At a Glance
- Age
- 1 Month – 3
- Sex
- Any
- Trial phase
- Phase 1/2
- Study type
- Interventional
- Purpose
- Other
- Participants needed
- 105 (estimated)
- Sponsor
- University of Nebraska · Other
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About This Trial
Butyric acid has been shown to promote gut health and improve the microbiome in multiple adult studies. In preliminary studies in older children with inflammatory bowel disease, butyric acid was shown to be safe. However, it's suitability for infants and young children with congenital heart disease (CHD) has yet to be determined.
This study will examine butyric acid supplementation in infants and…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Infants and Children undergoing cardiac surgery with cardiopulmonary bypass
Exclusion Criteria:
* Antibiotics, surgery, or chemotherapy within the past 8 weeks
* Continuous enteral feeds before surgery
* GI pathology or intestinal surgery (excluding G-tube)
* Liver disease w…
Contacts