Three miRNA Signatures in Glioma: From Molecular Mechanisms to Potential Clinical Application
Recruiting
Observational Study
Glioma
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
At a Glance
- Sex
- Any
- Study type
- Observational
- Participants needed
- 10 (estimated)
- Sponsor
- Regina Elena Cancer Institute · Other
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About This Trial
Individual overexpression of the three miRNAs negatively affects cell viability and proliferation mainly in grade III IDH-wild type cells, while in higher grade cells, the effect is more pronounced when the entire signature is overexpressed, individual and combined overexpression of the signature members is able to determine a significant reduction in both migration and invasion. Therefore, ectopi…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* histological diagnosis of glioma;
* no concomitant primary tumor;
* no metastatic disease;
* availability of surgical material/tissue;
* written informed consent.
Exclusion Criteria:
* histological diagnosis of non-glial tumor;
* patients with concomitant other solid tumors;…
Contacts