No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
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At a Glance
Age
18 – 80
Sex
Any
Study type
Observational
Participants needed
1,000 (estimated)
Sponsor
Beijing Anzhen Hospital · Other
Who this trial is looking for
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To identify plasma multi-omics biomarkers that predict left ventricular adverse remodeling (LVAR) and major adverse cardiovascular events (MACE) in patients with acute ST-segment elevation myocardial infarction, and to investigate the molecular pathways linked to LVAR and MACE.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
1. Age ≥18 years and ≤80 years.
2. Definite diagnosis of STEMI according to ESC/ACC guidelines:
* Chest pain lasting \>30 minutes, and
* ST-segment elevation in at least two contiguous leads: ≥0.2 mV in leads V2-V3 (≥0.2 mV for men, ≥0.15 mV for women) or ≥0.1 mV in other…
Inclusion Criteria:
1. Age ≥18 years and ≤80 years.
2. Definite diagnosis of STEMI according to ESC/ACC guidelines:
* Chest pain lasting \>30 minutes, and
* ST-segment elevation in at least two contiguous leads: ≥0.2 mV in leads V2-V3 (≥0.2 mV for men, ≥0.15 mV for women) or ≥0.1 mV in other leads, or new-onset left bundle branch block.
3. Reperfusion therapy: Symptom onset to first medical contact ≤12 hours, and successful primary PCI (culprit vessel opened, post-procedure TIMI flow grade 3).
4. First STEMI (no prior history of myocardial infarction).
5. Left ventricular ejection fraction (by echocardiography within 24-48 hours after admission) ≥35%.
6. Informed consent: Signed informed consent obtained, with willingness to undergo serial blood sampling and echocardiographic follow-up.
Exclusion Criteria:
1. Non-atherosclerotic MI: coronary embolism, spasm, aortic dissection, myocarditis, Takotsubo.
2. Severe comorbidities:
* Prior HF (NYHA ≥II);
* Severe CKD (eGFR \<30 mL/min/1.73m² or dialysis);
* Severe liver disease (Child-Pugh B/C);
* Active malignancy (life expectancy \<1 year);
* Severe hematologic disorders (thrombocytopenia, coagulopathy, active bleeding).
3. Fibrinolysis-followed-by-PCI.
4. Primary PCI complications:
* No-reflow/slow-flow (final TIMI \<2);
* Cardiogenic shock or mechanical complication within 7 days;
* In-hospital repeat revascularization.
5. Inability to complete 6-month follow-up.
6. Factors affecting blood sampling/exosome/immune/proteome assays:
* Blood transfusion within 1 month;
* Known hemolytic disorder;
* Inadequate venous access.
7. Pregnancy or lactation.
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